The above findings also raised questions about physiological relevance in health and disease, especially in light of recent genetic findings implicating DHTKD1 and OGDHL (encoding an E1o-like protein) in the genetic etiology of several metabolic disorders [11,12,13,14,15,16,17], such as eosinophilic esophagitis (EoE), a chronic allergic disorder (19), and selected neurodegenerative diseases [18]. This evidence concerns the gene DHTKD1 and eosinophilic esophagitis.