Because cellular stresses associated with cardiovascular disease perturb Golgi trafficking of VWF, resulting in smaller or more rounded WPBs [5], we next asked whether rounded WPBs in HCMECD are smaller than rod-shaped WPBs in HCMECC. To determine this, we estimated the volume distributions for WPBs in HCMECD and HCMECC, respectively. The gene discussed is VWF; the disease is cardiovascular disorder.