The sustained stimulation of lipolysis mediated by GH plays not only a major role in the development of hyperinsulinemia, insulin resistance and prediabetes/diabetes, but also in the reduction of lipid accumulation and the development of disadvantageous metabolic changes and comorbidities, such as hypertension, cardiovascular diseases, malignant neoplasms, and the resulting decreased life expectancy [91]. Here, GH1 is linked to Insulin resistance.