Moreover, individuals with the Laron syndrome showed reduced insulin concentrations (1.4 μU/mL versus 4.4 μU/mL in unaffected relatives) and a very low HOMA-IR (homeostatic model assessment-insulin resistance) index (0.34 versus 0.96 in unaffected relatives), indicating that higher insulin sensitivity could provide a possible (alternative) mechanism explaining the reduced prevalence of type 2 diabetes and cancer observed in subjects with the Laron syndrome [88]. Here, INS is linked to Laron syndrome.