In Mycobacterium tuberculosis, the most studied infection, vitamin D-induced cathelicidin acts as a second messenger to activate autophagy genes, such as autophagy related 5 (ATG5) and beclin-1 (BECN1), and triggers a downstream wide signaling cascade, including intracellular calcium (Ca2+) release, Ca2+-dependent kinases, extracellular ATP-gated ion channel, purinergic receptor (P2X) 7, mammalian target of rapamycin (mTOR)/AMP-activated protein kinase (AMPK)/phosphoinositide 3-kinase(PI3K) pathway, and reactive ROS signaling [92,93,94]. This evidence concerns the gene BECN1 and infection.