The results showed that inhibitors of several proteins, i.e., Aurora kinase inhibitors, bromodomain and extra-terminal motif (BET), Fms related receptor tyrosine kinase 3 (FLT3), histone deacetylase (HDAC) inhibitors, and Janus kinase (JAK), reduced the growth of all CS cell lines (independent of the IDH mutations status) [43]. This evidence concerns the gene IDH2 and Cowden syndrome 1.