It was associated with increased expression of the epithelial-specific markers Mammary serine protease inhibitor (Maspin), encoded by the serine protease inhibitor b5 (SERPINB5), and 14-3-3σ, encoded by Stratifin (SFN), during the development and progression of CS cells after DAC treatment with DAC (Table 1) [19]. Here, SERPINB5 is linked to Cowden syndrome 1.