Another inflammasome important in the context of MPN disease is the absent in melanoma 2 (AIM2), which recognizes double-stranded DNA (dsDNA) [207,208], and Liew et al. [209] identified AIM2 as a downstream target of JAK2V617F in hematological cell lines expressing JAK2V617F. The gene discussed is AIM2; the disease is myeloproliferative neoplasm.