In addition to this potential role of CDK6 to regulate both apoptosis and NET formation in neutrophils, it was also observed, in JAK2V617F progenitor cells, that the CDK6 protein acts as a transcriptional regulator of NF-κB signaling, apoptosis and malignant stem cell activation, which mainly illustrates the kinase-independent and non-catalytic functions of CDK6 in MPN pathogenesis [220]. The gene discussed is CDK6; the disease is myeloproliferative disorder.