The findings that MPN neutrophils are primed for NET formation [100,101] and that the signaling pathways and regulatory molecules such as the JAK, STAT, AKT and Raf-MEK-ERK signal transduction pathway—which may regulate both apoptosis and NETs in normal neutrophils or neutrophils under pathological conditions [100,103,104,105,106]—are upregulated in MPNs [5,12,14,15,16,17,18,34] encouraged us to discuss the potential pathophysiological relevance of NET formation in MPNs in this review. This evidence concerns the gene AKT1 and myeloproliferative neoplasm.