Although it has been well known since the 1990s that both the tissue plasminogen activator (tPA) and its inhibitor PAI-1 (type-1 plasminogen activator inhibitor) are stress-responsive proteins [1,2], containing glucocorticoid hormone (GC)-responsive elements (GRE) in their promoter sequences [3,4,5,6], their involvement in the context of stress-related psychiatric disorders has been poorly investigated in comparison with studies focusing on their role as fibrinolytic system modulators [7]. This evidence concerns the gene SERPINE1 and psychiatric disorder.