Furthermore, although tPA/PAI-1 imbalance was not investigated in a study from Stratta and colleagues, clinical correlates were demonstrated between BDNF expression and PTSD in subjects experiencing a traumatic event (i.e., earthquake-type natural disaster), showing a lower BDNF level for PTSD subjects than subjects with partial PTSD and controls [156]. Here, SERPINE1 is linked to post-traumatic stress disorder.