The study conducted on the YAC128 mouse HD model has also shown a beneficial effect of sodium butyrate supplementation, as the treated group displayed improved learning and motor skills, as well as improved cortical energy levels and increased histone 3 acetylation, suggesting that butyrate acting as an HDAC inhibitor can improve mitochondrial and transcriptional dysfunctions present in HD [29]. This evidence concerns the gene HDAC9 and Huntington disease.