Lastly, analyses involving a larger number of healthy individuals and patients with Mendelian FH, common lipid-metabolism-related disorders such as CAD, and Alzheimer’s disease can give us a greater insight into variations of the LDLR gene at the population level in different ethnic groups and will be helpful for early prevention or prognosis of these disorders. This evidence concerns the gene LDLR and early-onset autosomal dominant Alzheimer disease.