TP53 and central nervous system cancer: Such parallel mutations occur in low-grade gliomas for IDH1 as previously described, but can also be found in other genes for proteins like EGFR (epidermal growth factor receptor) [16], TP53 (human tumor protein 53) [17], PTEN (Phosphatase and tensin homologue deleted on chromosome 10) [16], and RB1 (retinoblastoma tumor suppressor) [16].