Regarding the cis results of the F13% group, the top three terms of the red cluster were “Parkinson disease”, “Oxidative phosphorylation”, and “Amyotrophic lateral sclerosis”; the terms of the blue cluster were “Leukocyte transendothelial migration”, “Tight junction”, and “Renin-angiotensin system”; and the terms of the yellow cluster were “Ribosome”, “Wnt signaling pathway”, and “Ubiquitin mediated proteolysis” (Figure 4B, Table S5). Here, REN is linked to amyotrophic lateral sclerosis.