The experimental results of 1/3 NT + STZ 75 mg/kg compared with STZ 75 mg/kg reached the expected index Albumin-Creatinine Ratio of 200 mg/g or more while the result of 1/3 NT + STZ 100 mg/kg compared with STZ 100 mg/kg has increased ACR to more than 300 mg/g (p < 0.05 and p < 0.01, respectively) (Figure 3A) with severe proteinuria, which destroyed glomerular and renal tubular cells in the kidney, making it from chronic renal failure to early renal failure. Here, ALB is linked to chronic kidney disease.