The presence of genetic lesions that drive distinct subtypes of leukemia has set the bases of ALL classification, in which novel categories defined by point mutations (such as PAX5 p.P80R or IKZF1 p.N159N) and additional gene fusions (i.e., ZNF384 or MEF2D rearrangements) have been recently acknowledged [3,4]. The gene discussed is IKZF1; the disease is acute lymphoblastic leukemia.