He et al. investigated DMC1 mutation in a consanguineous family with POI and non-obstructive azoospermia (NOA) members through WES and found a new missense mutation in DMC1, which was the causal mutation in both POI and NOA (c.106G > A, p.Asp36Asn) [50]. The gene discussed is DMC1; the disease is Azoospermia.