High levels of pro-angiogenic factors, such as VEGF, basic fibroblast growth factor (bFGF), platelet-derived growth factor (PDGF), and angiopoietin (Ang), results in abnormal vascular structure formation in the tumor bed and stimulates nutrient and oxygen supply to tumor cells, thereby promoting tumor progression [9,10]. This evidence concerns the gene FGF2 and neoplasm.