EC stimulation with the agonist of innate immune sensor melanoma differentiation-associated protein 5 (MDA5) induced the production of type I interferon and T cell-recruiting chemokines, such as CXCL9 and CXCL10, leading to increased tumor-infiltrating CD8+ T cells and an augmented anti-tumor immune response [77]. This evidence concerns the gene IFIH1 and neoplasm.