Other recurrently mutated genes in cutaneous melanomas include the proto-oncogene c-Kit (KIT), telomerase reverse transcriptase (TERT), Rac family small GTPase 1 (Rac1), phosphatase and tensin homolog (PTEN), and tumor protein p53 (TP53) [42,43,44]. The gene discussed is RAC1; the disease is cutaneous melanoma.