Although the immunological study suggests that the VLPs of CΔ116-MrNV-CPβ-RBD and CΔ116-MrNV-CPδ-RBD are potential COVID-19 vaccines, a virus challenge study in animal models will provide insights into the protective efficacy of the chimeric VLPs against SARS-CoV-2 infection. Here, CPB1 is linked to COVID-19.