Barbagallo et al. showed in two types of CRC cell lines (HCT-116, Caco-2) that urothelial cancer associated 1 (UCA1), also a lncRNA, can act as a RNA regulator for colorectal cancer progression by modulating the ceRNA network, thus upregulating ANLN, BIRC5, IPO7, KIF2A and KIF23 in two ways: (1) miRNAs sponge effects determining negative expression, and (2) the direct binding of mRNAs to 3′-UTRs to protect them from degradation. This evidence concerns the gene UCA1 and colorectal cancer.