FBXW7 and neoplasm: In colorectal cancer, CAF-derived exosomes loaded with miR-92a-3p are aimed at FBXW7 and MOAP1 in the tumor microenvironment and further activate the WNT/β-catenin pathway, inhibit mitochondrial apoptosis, leading to cell stemness, epithelial–mesenchymal transition, tumor metastasis and resistance to 5-FU/L-OHP [55].