Recently, it has been demonstrated that the expression of MAPK/p38α protein is upregulated in the brain of APP-PS1 transgenic AD mouse, whereas the knockdown of MAPK in the APP-PS1 mouse stimulates macroautophagy/autophagy, reducing amyloid pathology by increasing autophagic-lysosomal degradation of BACE1 [84]. Here, APP is linked to Alzheimer disease.