For instance, the higher expression of the stress- and inflammation-related genes Egr1, Jun, and Fos in aorta macrophages than in lung macrophages and their association with LM gene regulation, despite their similar RNA-Seq profiles, might account for a physiological advantage in the aorta by enabling a sufficient LM response to stress stimuli, such as hypertonia. The gene discussed is EGR1; the disease is Hypertonia.