TGFB1 and hepatocellular carcinoma: Consistently, as shown in Figure 4C, GSVA revealed that metabolism-related signals were markedly activated in HCC patients with high RAB scores, including xenobiotic metabolism, bile acid metabolism, and fatty acid metabolism, while oncogenic-related signaling pathways were remarkably activated in HCC patients with low RAB scores, including cell cycle-related signaling, EMT, the PI3K/AKT/mTOR signaling pathway, and the TGF-β signaling pathway.