Notably, both the gene ontology (GO)-biological processes and KEGG pathway enrichment analyses suggested that HCC in RAB cluster 1 was markedly associated with abnormal tumor metabolism, including metabolic pathways, drug metabolism, lipid metabolism, and amino acid metabolism, whereas HCC in RAB cluster 2 was significantly associated with aberrant activation of oncogenic signaling pathways, including PI3K/AKT signaling pathways, pathways in cancer, focal adhesion, and tight junction (Figure S2A). This evidence concerns the gene AKT1 and hepatocellular carcinoma.