AKT1 and hepatocellular carcinoma: Interestingly, gene set variation analysis (GSVA) indicated that HCC of RAB cluster 1 not only had the most remarkable correlation with metabolic pathways such as xenobiotic metabolism, bile acid metabolism, and fatty acid metabolism, but also had a strong association with immune signals such as the interferon-gamma/alpha response, while RAB cluster 2 in HCC was significantly associated with cell cycle regulation, the TGF-β signaling pathway, the PI3K/AKT/mTOR signaling pathway, and epithelial-mesenchymal transition (EMT) (Figure S2B).