Based on the above analysis, we realized that HCC could be classified into three subtypes with distinct TME characterization based on RAB-associated gene signatures, namely: RAB subtype-1, oncogenic signal suppression, metabolic activation, immune-desert, tumor stemness, ferroptosis sensitivity, and high TMB; RAB subtype-2, oncogenic signal activation, metabolic suppression, immune-excluded and ferroptosis tolerance; and RAB subtype-3, oncogenic signal suppression, metabolic suppression, and immune-inflamed. Here, AGFG1 is linked to neoplasm.