AGFG1 and hepatocellular carcinoma: Moreover, our TIDE analysis revealed that RAB cluster 1 in HCC had lower levels of cancer-associated fibroblasts (CAFs) and myeloid-derived suppressor cells (MDSCs), as well as a higher microsatellite steady state (MSI), whereas HCC of RAB cluster 2 was directly associated with immune exclusion (Figure 2G).