Given that FHL2 has been mechanistically associated with insulin secretion [24,26], diabetic kidney disease [25], and obesity [27], and that SNPs and epigenetic changes in FHL2 are associated with T2D [24] and body fat mass [28], we hypothesized that FHL2 genetic variants may also be associated with specific markers of glucose and lipid metabolism such as fasting plasma glucose values and plasma TG concentrations in humans. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.