Therefore, the main purpose of this study was to detect the coexistence of IGF-2, IGF-1R, and miR-483 and their synergic action in pterygium, aiming to support the proposition that considers pterygium a benign lesion, wherein the uncontrolled epithelial cell proliferation is the result of autocrine/paracrine cell activation and dysregulation of apoptosis. Here, IGF2 is linked to pterygium.