In our study, the specific IHC overexpression ofIGF-2 was observed in 93.6% of the examined pterygium samples, with the immunostaining detected in the cytoplasm of epithelial cells being localized in the basal and suprabasal layers; moreover, in nine (9/45, 20%) samples, the IGF-2-positive cells spread across the superficial layers of the epithelium. The gene discussed is IGF2; the disease is pterygium.