PRMT5 and colorectal cancer: (S)-2-(Cyclobutylamino)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)isonicotinamide (EPZ015866) is another PRMT5 specific inhibitor, which blocks the enzyme activity of PRMT5 in the proliferation and cell cycle progression of human colorectal cancer cells [26].