All of our data suggest that CD4 T cells from TCF-1 cKO mice can migrate to GvHD target organs, but also provided stronger evidence that TCF-1 is critical for CD4 T cell stemness, however due to the loss of TCF-1 on CD4 T cells, these CD4 T cells are unable to cause persistence of GvHD symptoms. Here, TCF7 is linked to graft versus host disease.