Additionally, deteriorated NO production in chronic HF exhibits detrimental effects in the expression of Vascular endothelial growth factor (VEGF), which normally mediates angiogenesis; as a result, diminuted capillary density occurs, which along with the dysfunctional energy metabolism of cardiomyocytes progress to the development of cardiomyopathy [83,84]. The gene discussed is VEGFA; the disease is cardiomyopathy.