Interestingly, despite the proven association with CAC (Figure 2B,D), TIMP1, MMP7, and ADAM8 were activated in IBD-affected colon tissues (Figure 5A), which is fully in line with our data: the high expression of these genes was demonstrated in DSS-inflamed and adjacent to adenomas colon tissues in mice (Figure 3D). The gene discussed is TIMP1; the disease is inflammatory bowel disease.