Analysis of the mention of acute colitis-related core genes (Figure 1B) alongside the keywords “Colitis”, “Crohn’s”, “Dysplasia”, and “Colon cancer” in scientific texts deposited in the MEDLINE database revealed the most studied genes in the field of colitis (Tnf, Il1b, Mmp9, Igf1, Ccl2, Slc26a2, Timp1, Lcn2, Il1a, and Sell); the majority of them occupied hub positions in retrieved colitis-associated gene networks (key nodes) (Figure 2A). This evidence concerns the gene MMP9 and malignant colon neoplasm.