TIMP1 and neoplasm: Note that adenomatous and adjacent tissues in mice with CAC mainly differed in the expression of the following genes: Tyrobp and Timp1 were found to be 1.9 and 1.7 times overexpressed in adenomas compared with the adjacent counterparts, respectively, whereas Mmp3 and Mmp9 were 7.6 and 13.9 times suppressed in tumor tissue, respectively (Figure 3D).