CTLA4 and adenocarcinoma: Further text mining study, combined with the computing of the association of CAC-related core genes with the overall survival of patients with colon (COAD) and rectal (READ) adenocarcinomas, clearly confirmed the credibility of our bioinformatics analysis: the most reported CAC-related genes (Tnf, Cd44, Timp1, Mmp7, Ctla4, Clu, Il1a, Hp) were not only associated with poor prognosis in COAD and READ patients but also occupied the hub positions in the networks retrieved from CAC-associated DEGs (Figure 2D).