In addition, the interferon-responsive gene Ifitm3 is critical to early colon cancer development [12,39], along with S100a9 and Slpi, which, when highly expressed in inflamed colon tissues in mice and patients with colitis and IBD, respectively, can be considered as potent amplifiers of tumor invasion [40,41]. Here, IFITM3 is linked to malignant colon neoplasm.