HP and neoplasm: According to the published reports, the acute-phase genes Hp, Lcn2, Lrg1, and Serpina3n included in this list are not only activated in response to inflammatory stimuli, but their aberrant expression is also strongly implicated in tumorigenesis: high levels of Hp and Lcn2 resulted in glucose metabolic dysfunction, angiogenesis, and metastasis in different tumor types [35,36], and Lrg1 and Serpina3n were associated with epithelial–mesenchymal transition in colorectal cancer [37,38].