The sub-clade of the most overexpressed DEGs included genes related to immune response (Ccl3, S100a9, S100a8, Cxcl2) and heme metabolism (Hp), whereas the most suppressed core genes in the colitis group were Hao2 and Slc26a3, associated with fatty acid metabolism and chloride ion transport, respectively (Figure 1B). This evidence concerns the gene HP and colitis.