The chronification of colonic inflammation led to significant reduction in the expression of C3, Tyrobp, Mmp3, and Timp1 in the adjacent to adenomas colonic tissue by 17.5, 6.6, 2.8 and 46.1 times compared with the samples from acute colitis group, and, moreover, the expression of C3 and Tyrobp in this compartment decreased to the healthy level (Figure 3D). The gene discussed is TIMP1; the disease is adenoma.