APP and Alzheimer disease: However, when the cases (AD and control) and the two RNA variants were studied together in the model, relative expression ratios of the two transcripts (circAPP/APP) were maintained in the AD cases and controls (99.94% and 99.90% lower circAPP (hsa_circ_0007556) relative to APP mRNA, respectively, p-value = 0.100), meaning that the decrease in expression of the 2 RNA variants is proportional within AD cases, although only circAPP (hsa_circ_0007556) was significantly decreased in samples with AD compared to controls (Figure S2).