To evaluate whether the magnitude of the differences in the transcript expression levels between AD cases and controls was gender-dependent, we included in the multivariate linear regression models the interaction between the presence/absence of the disease and gender, resulting in non-statistically significant interactions (circAPP (hsa_circ_0007556), p-value = 0.544 and for APP mRNA, p-value = 0.549). This evidence concerns the gene APP and Alzheimer disease.