EZH2 and melanoma: When looking at the BRAF V600+ subset, however, the number of driver genes with at least one CNV event was higher, albeit not significantly, in NR than in R. Interestingly, the most frequent melanoma driver genes showing amplifications were HRAS (11p15.5), GNA11 (19p13.3), STK19 (6p21.33), MAP2K2 (19p13.3), EZH2 (7q36.1), TERT (5p15.33), and MTOR (1p36.22), whereas the most frequently deleted region was located in the chromosome 10 cytoband 10q23.31 containing the PTEN gene.