Animal models for AD include chemically induced ones (e.g., amyloid infusion and streptozotocin), spontaneous ones (e.g., senescence-accelerated mouse), and several transgenic mice and a few transgenic rats that express mutant human genes related to the production of amyloid plaques and neurofibrillary tangles (e.g., 3XTg and 5XFAD, TG2576, and APP/PS1) [147]. Here, APP is linked to Alzheimer disease.