Next, authors reported the capacity of both native (gelsoline, histone H2B/H4, myeloperoxidase (MPO)) and citrullinated peptides (Histone H2B and proteoglycan 4) to trigger IFN-γ and CD40L expression on circulating CD4+ T cells from 29 RA patients as compared to 12 healthy controls. This evidence concerns the gene CD4 and rheumatoid arthritis.