Latent HHV including CMV infections enhance CD8+ effector and TRM cells’ immunosenescence characterized by increased capacity to release IFN-γ, loss of the CD28 co-stimulatory signals, up-regulation of the inhibitory NK cell receptor leukocyte immunoglobulin-like receptor 1 (LIR-1 or CD85), migration toward the fractalkine gradient into inflamed tissues such as the synovium due to the expression of the chemokine receptor CXCR3, and an oligoclonal TCR repertoire [30,31,49]. The gene discussed is LILRB1; the disease is cytomegalovirus infection.