HLA-C and rheumatoid arthritis: The MHC–Col2 interaction is similar when comparing RA patients and healthy subjects carrying the DRB1*04:01 allele; however, the difference for RA patients resulted in a higher IFN-γ, IL-17, and IL-2 T cell response and an antigen specific repertoire that is correlated with clinical activity [66,69,70], and this effect is higher in early RA than in established RA [68].