According to the immunodominant CD4+ T cell RA-IEDB list (Table 4), the main DRB1-SE restricted peptides eluted from synovial tissues derive from highly conserved antigens such as molecular chaperones, synovial peptides, cross-reactive bacterial antigens, and extracellular matrix or cellular peptides with PTM modifications, mainly citrullination. The gene discussed is CD4; the disease is rheumatoid arthritis.