Along with low-frequency mutated genes (like AXIN1, ARID2, ARID1A, TSC1/TSC2, RPS6KA3, KEAP1, MLL2), TP53 and CTNNB1 are the next most common mutations, affecting 25%–30% of HCC patients. This evidence concerns the gene CTNNB1 and hepatocellular carcinoma.