CDKN2A and hepatocellular carcinoma: HCC has an incredibly diverse and complex genetic landscape [152] that has been clearly defined over the past 20 years, and this includes homozygous deletions on chromosome 9 and high-level DNA amplifications on chromosomes 6p21 (VEGFA) and 11q13 (FGF19/CNND1) (CDKN2A).