CTNNB1 and hepatocellular carcinoma: Indeed, overexpression of DKK1 was linked to beta-catenin cytoplasmic/nuclear accumulation in clinical HCC samples (p = 0.011, correlation coefficient = 0.144) in a group of 314 Chinese HCC patients, as a critical indicator of a poor clinical outcome in HCC patients (p = 0.011, correlation coefficient = 0.144) [93].