SERPINB3 and hepatocellular carcinoma: Squamous cell carcinoma antigen (SCCA), a serine protease inhibitor that is naturally present in skin, as well as immunocomplexes forms of SCCA and α-FP (SCCA-IC and AFPIC, respectively), have both been identified in HCC patients and have been suggested as potential useful markers for the detection of micro-metastases and for improving accuracy of HCC diagnosis of at-risk patients.