It should be noted that GCN2 isoforms lacking functional RWD domains are expressed in some organisms, such as in the parasite T. gondii, the malaria parasite P. falciparum and Dictyostelium, and can nevertheless be activated [17,18,19], indicating that these GCN2 isoforms are activated in a GCN1-independent way. The gene discussed is EIF2AK4; the disease is malaria.