Errors of paternally expressed genes/transcripts in this region do cause PWS and a second embedded imprinting center controls the maternally expressed UBE3A (ubiquitin-protein ligase E3A) gene causing Angelman syndrome when altered (deleted, mutated or by paternal disomy 15) (e.g., [7,16,17,29]). This evidence concerns the gene UBE3A and Angelman syndrome.