These may impact fetal phenotype, prognosis and development/behavior/psychiatry with the need for follow-up and long-term care, including echocardiography due to the higher risk of congenital anomalies and heart defects with developmental assessments from disturbances seen in those with the 15q11.2 BP1-BP2 deletion. Here, IGFBP2 is linked to congenital heart disease.