ACTA2 and neoplasm: Expression of COL5A2, ITGAV, SERPINH1, CALD1, SPARC, and ACTA2 were associated with downregulation of the interferon-α and interferon-γ response (Figure 4B), as well as downregulation of activated CD8 tumor infiltrating lymphocytes (Act CD8), which induced dendritic cells (iDC) and immature B cells (imm B) in the tumor microenvironment (Figure 4C).