Supernumerary teeth have also been reported to be associated with various malformation syndromes, including APC-associated familial adenomatous polyposis (FAP) [2,26,27], RUNX2-associated cleidocranial dysplasia [27,28,29], and TRPS1-associated tricho-rhino-phalangeal syndrome [27,30,31,32,33]. The gene discussed is APC; the disease is Familial adenomatous polyposis.