It can antagonize the negative effects mediated by RAS or the ACE/AngII /AT1 axis, such as lung inflammation, fibrosis, pulmonary arterial hypertension, and apoptosis of alveolar epithelial cells, suggesting an anti-inflammatory and organ-protective role of the ACE2 protein which, however, is also the receptor of SARS-CoV-2 [55]. The gene discussed is AGTR1; the disease is pulmonary arterial hypertension.