Additionally, a crossover randomized trial demonstrated that performing 3-min bouts of light-intensity walking every 30 min of sitting (total: 42 min) resulted in improved glycemic (i.e., glucose, insulin, and c-peptide) and inflammatory (i.e., IL-1β, IL-1ra, IL-10, and TNF-α) markers when compared to 8 h of prolonged, uninterrupted sitting in postmenopausal females with rheumatoid arthritis [52]. The gene discussed is INS; the disease is rheumatoid arthritis.