PPARG and obesity due to melanocortin 4 receptor deficiency: Scientific reports evaluating the anti-obesity effects of EO compared to orlistat—a specific gastrointestinal lipase inhibitor commonly used in obesity treatment that inhibits the absorption of fat, resulting in weight loss—concluded that sweet orange and cumin EOs are potential candidates to replace pharmacological obesity treatments through downregulation of PPARγ expression, consequently preventing preadipocytes [28,29,30,31].