They found that RTFP could significantly improve the insulin resistance in DB/DB diabetic mice, increase their SOD, GSH, and catalase (CAT) activities in liver tissue, significantly reduce the weight, fat, liver hypertrophy, fasting blood glucose, serum insulin, and blood lipid levels of mice, enhance their glucose tolerance, and significantly improve the symptoms of hyperglycemia and hyperlipidemia. The gene discussed is CAT; the disease is Insulin resistance.