It could also up-regulate the mRNA expression levels of AMP-activated protein kinase α (AMPK), glucose transporter 2 (GLUT2), acetyl-CoA carboxylases alpha (ACACA), fatty acid synthase (FASN) in liver tissue and down-regulate the mRNA expression levels of phosphoenolpyruvate carboxylase (PEPCK), glucose-6-phosphatase (G6Pase), HMG-CoA reductase (HMG-CoA) and cholesterol 7 α -hydroxylase (CYP7A1), significantly reduce the body weight, fat, liver hypertrophy and fasting blood glucose, serum insulin and lipid levels in db/db mice, and effectively alleviate the symptoms of type 2 diabetes [80]. Here, G6PC1 is linked to type 2 diabetes mellitus.