UCP2 and diabetes mellitus: They found that the RTFP-3-functionalized SeNPs (RP3-SeNPs) exhibited high dispersibility and stability, and could significantly inhibit the H2O2-induced apoptosis of INS-1 cells by attenuating oxidative stress and downregulating the expression of uncoupling protein-2 (UCP-2), which demonstrate that RP3-SeNPs may be a promising candidate for the treatment of ROS-mediated diabetes [54].