IGHE and wheat allergic reaction: Matsumoto et al. investigated effects of thioredoxin on the allergenicity of salt-soluble wheat proteins in six patients with IgE-mediated wheat allergy and found that the thioredoxin-treated wheat proteins mitigated both the reaction of the skin prick test and the binding to serum IgE by inhibition assay using fluorescence enzyme immunoassay using ImmunoCAP (CAP-FEIA) [64].