Using a traditional breeding method, Waga, et al. established a winter wheat line possessing hybrid genotypes lacking all ω-gliadin coding loci (Gli A1, Gli B1 and Gli D1) and investigated the reactivity of Serum IgE in several patients with wheat allergies (including asthma, rhinitis, urticaria/angioedema, anaphylaxis, and AD). Here, IGHE is linked to allergic disease.