Some of the epigenetic markers identified in our study, TMEM132D, MYO15B, TTC34, LTBR, and CLEC14A genes, whose methylation levels showed the best classification of BC sensitivity to NACT, were previously partially studied in terms of involvement in the etiopathogenesis of malignant neoplasms and potential use as diagnostic markers in oncology. Here, LTBR is linked to breast cancer.