Other relevant associations of HLA alleles or proteins with irAEs previously reported are those of HLA-DRB1*04:05 with inflammatory arthritis [159], HLA-B27*05 with autoimmune encephalitis [160], HLA-Cw12 with hypophysitis [153,161], HLA-DQB1*03:01 with colitis [162], HLA-DRB3*01:01 with thrombocytopenia [163], HLA-A03 with pneumonitis [164], and HLA DRB*04:01, HLA-DRB1*15:01 and HLA-DQB1*06:02 with hepatitis [165] (Table 3) [74,131,152,153,154,155,156,157,159,160,161,162,164,165,166,167,168,169]. The gene discussed is HLA-DRB1; the disease is hypophysitis.