Clinically relevant pathways, such as those of the inflammasome in ICI-induced myocarditis or the neutrophil activation cascade in gastrointestinal irAEs, have been identified through the overexpression of type 5 and 6 guanylate binding proteins and CD177 and CEACAM1 genes, respectively [140,141]. This evidence concerns the gene CEACAM1 and myocarditis.