Furthermore, certain germline CTLA4 and PDCD1 (encoding for PD-1 protein) gene polymorphisms have been associated with both the development of autoimmune diseases and susceptibility to ICI-induced endocrine irAEs [130] (Table 3) [131,132,133,134,135,136,137,138,139,140,141,142,143,144]. The gene discussed is CTLA4; the disease is autoimmune disease.