In many cases, TMB is a more reliable predictive marker for PD1 and PDL1 blockade immunotherapy response than PD1 or PDL1 expression; for example, the presence of ten or more mut/Mb was associated with improved response and prolonged progression-free survival, irrespective of tumor PDL1 expression in NSCLC [247,248]. The gene discussed is PDCD1; the disease is non-small cell lung carcinoma.