Fibroblasts are a major component of the tumor stroma which is known to promote tumor growth and progression, and recent studies have shown a correlation between the distribution of fibroblasts and macrophages in various cancers [14,15], and that fibroblasts can induce M2 macrophage polarization through the secretion of interleukin 6 and stromal cell-derived factor 1 [16]. Here, CXCL12 is linked to neoplasm.