As neuroendocrine tumors, partial PAs are known as functioning PAs with the capacity to secrete hormones including one or more of the following: growth hormone (GH), prolactin (PRL), adrenocorticotropic hormone (ACTH), thyroid stimulating hormone (TSH), gonadotropin (Gn), etc. Approximately 40% of PAs exhibit invasive features [3], and some of the associated factors that were reported include macroadenomas, GH-Pas, and sparsely granulated somatotroph adenomas [4]. Here, POMC is linked to familial isolated pituitary adenoma.