Our current sarcoma NGS panel as well as Caris transcriptome data was suitable for learning additional basic biology about EWS fusion genes including the exact breakpoint and intra- and intergroup similarities and differences involving EWS-FLI1, EWS-ERG, EWS-FEV, and EWS-WT1 in-frame polypeptides predicted by the fusion genes. The gene discussed is FLI1; the disease is sarcoma.