CD274 and breast carcinoma: According to the study, vaccination with high-density lipoprotein nanodisks (ND) loaded with ALDH epitopes reduced the frequency of ALDHhigh CSCs in tumor tissue when combined with anti-PD-L1 therapy, and it exerted strong inhibitory effects on tumor growth in the syngeneic D5 melanoma and 4T1 breast cancer models [247].