Thus, an excess of polyamines could induce the downregulation of SOCE modulatory genes (STIM1,2), the plasma membrane Ca2+ ATPase PMCA4 Ca2+ pump, and the mitochondrial Ca2+ channels MCU and VDAC3, contributing to dysregulated SOCE and enhanced resting Ca2+ and mitochondrial Ca2+ uptake in CRC. This evidence concerns the gene ATP2B4 and colorectal carcinoma.