In the differentiation of benign ovarian tumors from malignant ovarian cancer, the combination of TK1p + ROMA index had a higher sensitivity of 66% followed by TK1p + HE4 at 58% and TK1p + CA 125 at 43.5%, compared to TK1p at 28% alone. The gene discussed is WFDC2; the disease is ovarian benign neoplasm.